Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner.

@article{Pisani2016EstrogenRA,
  title={Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner.},
  author={Samantha L. Pisani and Steven L. Neese and John A. Katzenellenbogen and Susan L. Schantz and Donna L Korol},
  journal={Endocrinology},
  year={2016},
  volume={157 1},
  pages={
          292-303
        }
}
Estrogens are well known for their enhancing effects on hippocampus-sensitive cognition. However, estrogens can also impair learning and memory, particularly the acquisition of striatum-sensitive tasks. These cognitive shifts appear to be mediated through local estrogen receptor (ER) activation in each neural structure, but little information is known regarding which specific ER subtypes drive the opposing effects on learning. Elucidating the mnemonic roles of discrete ER subtypes is essential… CONTINUE READING
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