Estrogen Receptor Beta (ESR2) Polymorphisms in Familial and Sporadic Breast Cancer

@article{Maguire2005EstrogenRB,
  title={Estrogen Receptor Beta (ESR2) Polymorphisms in Familial and Sporadic Breast Cancer},
  author={Paula Maguire and Sara Margolin and Johanna Skoglund and Xiaofeng Sun and Jan-{\AA}ke Gustafsson and Anne-Lise B\orresen-Dale and A. Arto Lindblom},
  journal={Breast Cancer Research and Treatment},
  year={2005},
  volume={94},
  pages={145-152}
}
Estrogen is involved in both normal mammary development and in breast carcinogenesis. A family history of disease and exposure to estrogen are major risk factors for developing breast cancer. Estrogen exerts its biological effects through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2). Genetic variation in genes involved in estrogen biosynthesis, metabolism and signal transduction have been suggested to play a… CONTINUE READING
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