Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*

@article{Yamamoto2006EstrogenR,
  title={Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*},
  author={Y. Yamamoto and R. Moore and Holly A Hess and G. Guo and F. Gonzalez and K. Korach and R. R. Maronpot and M. Negishi},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={16625 - 16631}
}
  • Y. Yamamoto, R. Moore, +5 authors M. Negishi
  • Published 2006
  • Biology
  • Journal of Biological Chemistry
  • Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor (CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile acid toxicity. However, no nuclear receptor has been… CONTINUE READING
    123 Citations

    Figures from this paper

    Role of Pituitary Hormones on 17α-Ethinylestradiol-Induced Cholestasis in Rat
    • 28
    • PDF
    Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat.
    • 17
    • Highly Influenced
    • PDF
    Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats
    • 23
    Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries.
    • 17
    • Highly Influenced
    Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor
    • 19
    • PDF
    Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice
    • 22
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 38 REFERENCES
    Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
    • C. Stedman, C. Liddle, +5 authors M. Downes
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 187
    • PDF
    The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • 1,143
    • PDF
    An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    • 688
    • PDF
    Protective Role of Hydroxysteroid Sulfotransferase in Lithocholic Acid-induced Liver Toxicity*
    • 133
    • PDF