Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*

@article{Yamamoto2006EstrogenR,
  title={Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*},
  author={Y. Yamamoto and R. Moore and Holly A Hess and G. Guo and F. Gonzalez and K. Korach and R. R. Maronpot and M. Negishi},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={16625 - 16631}
}
  • Y. Yamamoto, R. Moore, +5 authors M. Negishi
  • Published 2006
  • Biology
  • Journal of Biological Chemistry
    • Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor (CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile acid toxicity. However, no nuclear receptor has been… CONTINUE READING
    View on ASBMB
    jbc.org
    123 Citations
    Highly Influencial Citations
    5
    Background Citations
    35
    Methods Citations
    2
    Results Citations
    5

    Figures from this paper

    Figures

    123 Citations
    Citation Type

    Citation Type

    Role of Pituitary Hormones on 17α-Ethinylestradiol-Induced Cholestasis in Rat
    • 28
    • PDF
    Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat.
    • 17
    • Highly Influenced
    • PDF
    Molecular mechanism of 17α-ethinylestradiol cytotoxicity in isolated rat hepatocytes.
    • 6
    Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats
    • 23
    Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries.
    • 17
    • Highly Influenced
    Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor
    • 19
    • PDF
    Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway
    • 4
    • PDF
    Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor–mediated suppression of the estrogen sulfotransferase SULT1E1
    • 6
    • PDF
    Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice
    • 22
    • Highly Influenced
    • PDF
    Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP
    • 9

    References

    SHOWING 1-10 OF 38 REFERENCES
    Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
    • C. Stedman, C. Liddle, +5 authors M. Downes
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 187
    • PDF
    The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • 1,143
    • PDF
    The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity*
    • 199
    • PDF
    Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice
    • 90
    Estrogen receptor α, but not β, plays a major role in 17β-estradiol-induced murine cholesterol gallstones
    • 58
    An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    • 688
    • PDF
    Protective Role of Hydroxysteroid Sulfotransferase in Lithocholic Acid-induced Liver Toxicity*
    • 133
    • PDF
    Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity*
    • 269
    • PDF
    Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.
    • 35
    Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
    • 453
    • PDF