Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*

  title={Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*},
  author={Y. Yamamoto and R. Moore and Holly A Hess and G. Guo and F. Gonzalez and K. Korach and R. R. Maronpot and M. Negishi},
  journal={Journal of Biological Chemistry},
  pages={16625 - 16631}
  • Y. Yamamoto, R. Moore, +5 authors M. Negishi
  • Published 2006
  • Biology
  • Journal of Biological Chemistry
  • Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor (CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile acid toxicity. However, no nuclear receptor has been… CONTINUE READING
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