Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*
@article{Yamamoto2006EstrogenR, title={Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity*}, author={Y. Yamamoto and R. Moore and Holly A Hess and G. Guo and F. Gonzalez and K. Korach and R. R. Maronpot and M. Negishi}, journal={Journal of Biological Chemistry}, year={2006}, volume={281}, pages={16625 - 16631} }
Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor (CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile acid toxicity. However, no nuclear receptor has been… CONTINUE READING
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