Estrogen Protects Lenses against Cataract Induced by Transforming Growth Factor-β (TGFβ)

  title={Estrogen Protects Lenses against Cataract Induced by Transforming Growth Factor-β (TGFβ)},
  author={Angela M. Hales and Coral G. Chamberlain and Christopher R. Murphy and John W. McAvoy},
  journal={The Journal of Experimental Medicine},
  pages={273 - 280}
Cataract, already a major cause of visual impairment and blindness, is likely to become an increasing problem as the world population ages. In a previous study, we showed that transforming growth factor-beta (TGFP) induces rat lenses in culture to develop opacities and other changes that have many features of human subcapsular cataracts. Here we show that estrogen protects against cataract. Lenses from female rats are more resistant to TGFbeta-induced cataract than those from males. Furthermore… CONTINUE READING


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Induction of subcapsular cataract in cultured weanling and adult rat lenses by TGFb2

  • A. M. Hales, C. G. Chamberlain, J. W. McAvoy
  • Invest. Ophthalmol. Visual Sci
  • 1996
1 Excerpt

Oestrogen and lens opacities in the Melton eye study

  • J. R. Thompson, J. S. Deane, A. B. Hall, A. R. Rosenthal
  • Invest. Ophthalmol. Visual Sci. 37:S585
  • 1996

The role of estrogen on cataract formation: a study of transgenic mice with mutation of estrogen receptor

  • C. C. Chan, V. L. Davis, T. Schoen, Q. Li, K. S. Korach, G.J
  • Chader
  • 1996
1 Excerpt

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