Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

@article{Nakamura2007EstrogenPB,
  title={Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts},
  author={T. Nakamura and Yuuki Imai and T. Matsumoto and Shingo Sato and K. Takeuchi and K. Igarashi and Y. Harada and Y. Azuma and A. Krust and Yoko Yamamoto and H. Nishina and S. Takeda and H. Takayanagi and D. Metzger and J. Kanno and K. Takaoka and T. Martin and P. Chambon and S. Kato},
  journal={Cell},
  year={2007},
  volume={130},
  pages={811-823}
}
  • T. Nakamura, Yuuki Imai, +16 authors S. Kato
  • Published 2007
  • Biology
  • Cell
  • Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor alpha (ERalpha) in mediating estrogen-dependent bone maintenance in female mice. We selectively ablated ERalpha in differentiated osteoclasts (ERalpha(DeltaOc/DeltaOc)) and found that ERalpha(DeltaOc/DeltaOc) females, but not males, exhibited trabecular bone loss, similar to the osteoporotic bone… CONTINUE READING
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