Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

@article{Nakamura2007EstrogenPB,
  title={Estrogen Prevents Bone Loss via Estrogen Receptor $\alpha$ and Induction of Fas Ligand in Osteoclasts},
  author={Takashi Nakamura and Yuuki Imai and Takahiro Matsumoto and Shingo Sato and Kazusane Takeuchi and Katsuhide Igarashi and Yoshifumi Harada and Yoshiaki Azuma and Andrée Krust and Yoko Yamamoto and Hiroshi Nishina and Shu Takeda and Hiroshi Takayanagi and Daniel Metzger and Jun Kanno and Kunio Takaoka and T John Martin and Pierre Chambon and Shigeaki Kato},
  journal={Cell},
  year={2007},
  volume={130},
  pages={811-823}
}
Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor alpha (ERalpha) in mediating estrogen-dependent bone maintenance in female mice. We selectively ablated ERalpha in differentiated osteoclasts (ERalpha(DeltaOc/DeltaOc)) and found that ERalpha(DeltaOc/DeltaOc) females, but not males, exhibited trabecular bone loss, similar to the osteoporotic bone… Expand

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