Estrogen Metabolite and Ligands of Death Receptor Family Pathways in Pancreatic Cancer : Synergistic Action of Crosstalk between Extrinsic and Intrinsic Cell Death

Abstract

2-Methoxyestradiol is a physiologicmetabolite of 17B-estradiol. This orally active compound can inhibit tumor growth or metastasis in tumor models without inducing any clinical sign of toxicity. Our previous studies indicated that 2-methoxyestradiol-mediated apoptosis involves the disappearance of intact 21-kDa Bid protein, cytochrome c release, and… (More)

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