Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.

@article{Chen2016EstrogenM1,
  title={Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.},
  author={Xinping Chen and Megha A. Talati and Joshua Patrick Fessel and Anna R Hemnes and Santhi Gladson and Jaketa French and Sheila D. Shay and Aaron Trammell and John A. Phillips and Rizwan Hamid and Joy Cogan and Elliott P. Dawson and Kristie E Womble and Lora K. Hedges and Elizabeth G Mart{\'i}nez and Lisa A. Wheeler and James E Loyd and Susan J Majka and James West and Eric D Austin},
  journal={Circulation},
  year={2016},
  volume={133 1},
  pages={82-97}
}
BACKGROUND Pulmonary arterial hypertension (PAH) is a proliferative disease of the pulmonary vasculature that preferentially affects women. Estrogens such as the metabolite 16α-hydroxyestrone (16αOHE) may contribute to PAH pathogenesis, and alterations in cellular energy metabolism associate with PAH. We hypothesized that 16αOHE promotes heritable PAH (HPAH) via microRNA-29 (miR-29) family upregulation and that antagonism of miR-29 would attenuate pulmonary hypertension in transgenic mouse… CONTINUE READING
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