Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors

  title={Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors},
  author={Melody V Wu and Devanand S. Manoli and Eleanor J. Fraser and Jennifer K. Coats and Jessica Tollkuhn and Shin-ichiro Honda and Nobuhiro Harada and Nirao M. Shah},
Sex hormones are essential for neural circuit development and sex-specific behaviors. Male behaviors require both testosterone and estrogen, but it is unclear how the two hormonal pathways intersect. Circulating testosterone activates the androgen receptor (AR) and is also converted into estrogen in the brain via aromatase. We demonstrate extensive sexual… CONTINUE READING
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