Corpus ID: 30738539

Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus

@inproceedings{Pierdominici2013EstrogenIO,
  title={Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus},
  author={Marina Pierdominici and Elena Ortona},
  year={2013}
}
 Abstract— Autoimmune diseases (ADs) are thought to result from a combination of genetics, environmental triggers, and stochastic events. Female prevalence in ADs and the effects of sex hormones on the immune system support a role for these hormones in the pathogenesis of ADs. Systemic Lupus Erythematosus (SLE) is a prototypical AD with a significant predominance in women, and estrogen is likely to play a pathogenic role in this disease. Estrogen's primary effects are mediated by transcription… Expand

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