• Corpus ID: 30738539

Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus

  title={Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus},
  author={Marina Pierdominici and Elena Ortona},
 Abstract— Autoimmune diseases (ADs) are thought to result from a combination of genetics, environmental triggers, and stochastic events. Female prevalence in ADs and the effects of sex hormones on the immune system support a role for these hormones in the pathogenesis of ADs. Systemic Lupus Erythematosus (SLE) is a prototypical AD with a significant predominance in women, and estrogen is likely to play a pathogenic role in this disease. Estrogen's primary effects are mediated by transcription… 

Tables from this paper

Autoantibodies to estrogen receptors and their involvement in autoimmune diseases and cancer

Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan

Evidence is provided from human epidemiological data and animal studies that endocrine transitions exert profound impact on the development of autoimmune diseases in women through complex mechanisms and could aid in prediction, prevention, and cures of these debilitating Diseases in women.

Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus

An altered ER profile in SLE patients is demonstrated, possibly contributing to SLE pathogenesis and interfering with clinical activity, and the potential exploitation of T cell-associated ERβ as a biomarker of disease activity is highlighted.

Role of Estrogen and Progesterone in Human Disorders - An Overview

The role of estrogen and progesterone in occurrence and development of various diseases is complex and controversial.

Sex-based differences in autoimmune diseases.

Possible mechanisms for sex specific differences in autoimmunity with a special focus on three paradigmatic diseases: systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis are discussed.

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus.

This study investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE and identified significant differences in the serum IL-19 levels between the different classes of SLE.

Vitamin D in autoimmune rheumatic diseases: A view inside gender differences

Effect of endocrine disruptor phytoestrogens on the immune system: Present and future.

  • G. Csaba
  • Biology
    Acta microbiologica et immunologica Hungarica
  • 2018
Phytoestrogen's effects appear in the progeny generations, and the generationally repeated disruptor effects will be different from the present ones, and this could also be manifested in the amount, type, and appearance of autoimmune diseases.

Gender differences in autoimmune disease

Women and Kidney Disease: Reflections on World Kidney Day 2018.

What the authors do and do not know about women, kidney health, and kidney disease, and what they might learn in the future to improve outcomes worldwide are focused on.



Estrogen Receptors in Immunity and Autoimmunity

The modulation of ERα function appears to be a potential target for therapy in autoimmunity and the protective effect of ERβ in lupus is multifactoral, and in arthritis models, ERα agonists appears to mediate a protective effect.

Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus.

Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity

The data shows that the enhancing role of estrogens on immune/inflammatory response is exerted by activating the NFkB complex pathway, suggesting new roles for estrogens in autoimmunity.

Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.

Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus.

The data suggest that anti-ERα autoantibodies interfere with T lymphocyte homeostasis and are significantly associated with lupus disease activity.

Systemic lupus erythematosus: a role for anti-receptor antibodies?

The complex role of estrogens in inflammation.

This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.

Differential expression of estrogen receptors in women with systemic lupus erythematosus.

Variation in the amount of ER-alpha in SLE T cells suggests this receptor subtype participates in the sensitivity of Sle T cells to estrogen, indicating that both ER subtypes activate calcineurin and CD154 in Sle but not in normal T cells.

Estrogen and CD4+ T cells

  • A. Pernis
  • Biology, Medicine
    Current opinion in rheumatology
  • 2007
Dissecting the molecular pathways employed by estrogen to modulate CD4+ T cells will be critical in elucidating the manner by which estrogen exerts its effects on this compartment, crucial to further exploitation of hormonal therapies in rheumatic autoimmune diseases.

Membrane estrogen and glucocorticoid receptors--implications for hormonal control of immune function and autoimmunity.