Estrogen Deficient Male Mice Develop Compulsive Behavior

  title={Estrogen Deficient Male Mice Develop Compulsive Behavior},
  author={R. Hill and K. McInnes and Emily C. H. Gong and M. E. Jones and W. C. Boon},
  journal={Biological Psychiatry},
  • R. Hill, K. McInnes, +2 authors W. C. Boon
  • Published 2007
  • Medicine
  • Biological Psychiatry
  • BACKGROUND Aromatase converts androgen to estrogen. Thus, the aromatase knockout (ArKO) mouse is estrogen deficient. We investigated the compulsive behaviors of these animals and the protein levels of catechol-O-methyltransferase (COMT) in frontal cortex, hypothalamus and liver. METHODS Grooming was analyzed during the 20-min period immediately following a water-mist spray. Running wheel activity over two consecutive nights and barbering were analyzed. COMT protein levels were measured by… CONTINUE READING
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