Estrogen Deficient Male Mice Develop Compulsive Behavior
@article{Hill2007EstrogenDM, title={Estrogen Deficient Male Mice Develop Compulsive Behavior}, author={R. Hill and K. McInnes and Emily C. H. Gong and M. E. Jones and W. C. Boon}, journal={Biological Psychiatry}, year={2007}, volume={61}, pages={359-366} }
BACKGROUND
Aromatase converts androgen to estrogen. Thus, the aromatase knockout (ArKO) mouse is estrogen deficient. We investigated the compulsive behaviors of these animals and the protein levels of catechol-O-methyltransferase (COMT) in frontal cortex, hypothalamus and liver.
METHODS
Grooming was analyzed during the 20-min period immediately following a water-mist spray. Running wheel activity over two consecutive nights and barbering were analyzed. COMT protein levels were measured by… CONTINUE READING
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