• DOI:10.1016/j.biopsych.2006.01.012
Corpus ID: 22669945

Estrogen Deficient Male Mice Develop Compulsive Behavior

@article{Hill2007EstrogenDM,
  title={Estrogen Deficient Male Mice Develop Compulsive Behavior},
  author={R. Hill and K. McInnes and Emily C. H. Gong and M. E. Jones and W. C. Boon},
  journal={Biological Psychiatry},
  year={2007},
  volume={61},
  pages={359-366}
}

R. Hill, K. McInnes, +2 authors W. C. Boon

Published 2007

Medicine

Biological Psychiatry

BACKGROUND Aromatase converts androgen to estrogen. Thus, the aromatase knockout (ArKO) mouse is estrogen deficient. We investigated the compulsive behaviors of these animals and the protein levels of catechol-O-methyltransferase (COMT) in frontal cortex, hypothalamus and liver. METHODS Grooming was analyzed during the 20-min period immediately following a water-mist spray. Running wheel activity over two consecutive nights and barbering were analyzed. COMT protein levels were measured by… CONTINUE READING

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