Estrogen Deficient Male Mice Develop Compulsive Behavior

@article{Hill2007EstrogenDM,
  title={Estrogen Deficient Male Mice Develop Compulsive Behavior},
  author={Rachel A Hill and Kerry J. McInnes and Emily C. H. Gong and Margaret E. E. Jones and Evan R. Simpson and Wah Chin Boon},
  journal={Biological Psychiatry},
  year={2007},
  volume={61},
  pages={359-366}
}
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93 Citations
Highly Influential Citations
7
Background Citations
37
Methods Citations
3
Results Citations
5

93 Citations

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Citation Type

Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls
Behavioral Analysis of Genetically Modified Mice Indicates Essential Roles of Neurosteroidal Estrogen
TLDR
The results suggest that estrogens locally synthesized in the specific neurons of the perinatal mouse brain directly act on the neurons and play crucial roles in the organization of neuronal networks participating in the control of sexual, aggressive, and locomotive (exploratory) behaviors.
Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight
TLDR
A requirement for AKAP13 in murine behavior is revealed, particularly in female mice, and is the first report of AKAP 13 involvement in murines behavior in a murine model of sex-dependent, compulsive-like behavioral changes.
A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse.
TLDR
The data suggest that estrogens act via ERα to regulate TG homeostasis in the ArKO liver, and confirmed by RT-PCR that only ERα is expressed in the mouse liver.
Effects of Aromatase Inhibition on the Physical Activity Levels of Male Mice.
TLDR
The recovery of wheelRunning in mice with androgen supplementation and the further persistence of wheel running in mouse with compromised aromatase function suggests that the androgens-testosterone in particular-may directly affect wheel running patterns in male mice.
Ovarian hormones modulate ‘compulsive’ lever-pressing in female rats
Psychotropic drug-induced locomotor hyperactivity and prepulse inhibition regulation in male and female aromatase knockout (ArKO) mice: role of dopamine D1 and D2 receptors and dopamine transporters
TLDR
Because of their lack of oestrogen production, it was anticipated that ArKO mice would display enhanced effects of amphetamine on locomotor activity and PPI, but in these animals, aromatase knockout appeared to be ‘protective’.
Neuroendocrine Inherited or Induced Aromatase Enzyme Deficits
TLDR
These aromatase–deficient patients confirmed that estrogen exerts a negative feedback on both the pituitary gland and the hypothalamus to modulate the levels of gonadotropin secreted from the anterior pituitsary.
Ovarian Sex Hormones Modulate Compulsive, Affective and Cognitive Functions in A Non-Induced Mouse Model of Obsessive-Compulsive Disorder
TLDR
The results indicate that already existing compulsions can be worsened during acute ovarian deprivation concomitant with exacerbation of affective behaviors and responses to hormonal intervention in OVX female mice can be influenced by genetic background.
Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats.
TLDR
Although the effect of estrogen on COMT activity in vivo in rats was explored, its effects were sex and tissue dependent and the estrogen down-regulation and tamoxifen up-regulation of COMT were best substantiated in the prefrontal cortex and kidneys where COMT is physiologically important for dopamine metabolism.
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References

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