Estrogen-Based Hormone Therapy for Depression Related to Reproductive Events

  title={Estrogen-Based Hormone Therapy for Depression Related to Reproductive Events},
  author={Alison Myoraku and Thalia K. Robakis and Natalie L. Rasgon},
  journal={Current Treatment Options in Psychiatry},
PurposeIn this review, we provide an overview of recent literature on the use of estrogen-based hormone therapy to treat depression related to reproductive events, like postpartum and perimenopause. Women are two to four times more likely to become depressed in the perimenopausal stage of life and as many as 14.5% of women develop postpartum depression. It is hypothesized that these depressive symptoms are a result of fluctuations in hormone levels during these windows of vulnerability. To… 



Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women.

This small study suggests that for some antidepressant-naive perimenopausal women with clinical depression, ERT may have antidepressant efficacy in depressed women who have minimal response to a selective serotonin reuptake inhibitor.

Effects of gonadal steroids in women with a history of postpartum depression.

The data provide direct evidence in support of the involvement of the reproductive hormones estrogen and progesterone in the development of postpartum depression in a subgroup of women and suggest that women with a history of post partum depression are differentially sensitive to mood-destabilizing effects of gonadal steroids.

Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial

Twelve months of TE+IMP were more effective than placebo in preventing the development of clinically significant depressive symptoms among initially euthymic perimenopausal and early postmenopausal women.

Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report.

Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation.

Hormones and menopausal status as predictors of depression in women in transition to menopause.

Hormone associations provided corroborating evidence that the changing hormonal milieu contributes to dysphoric mood during transition to menopause and decreased in postmenopausal women.

Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.

Transdermal estradiol replacement is an effective treatment of depression for perimenopausal women and sustained antidepressant benefit of treatment after the 4-week washout period, although somatic complaints increased in frequency and intensity.

Prescribing menopausal hormone therapy: an evidence-based approach

For women under the age of 60 years, or within 10 years of onset of natural menopause, MHT for the treatment of bothersome menopausal symptoms poses low risk and is an acceptable option, particularly when nonhormonal management approaches fail.

Transdermal Estradiol for Postpartum Depression: A Promising Treatment Option

Estradiol treatment for PPD requires confirmation of efficacy in a randomized clinical trial before routine clinical use as monotherapy, and additional data regarding maternal tolerability of cyclic progestins, long-term safety of estradiol treatment, and interdisciplinary collaboration among psychiatrists and gynecologists are needed.

Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study.

This preliminary study shows that depression symptoms may be rapidly reduced in patients with postpartum depression who have documented estradiol deficiency by treatment with 17beta-estradiol and suggests thatEstradiol can have significance in the pathophysiology of this condition and may be an option in the treatment of women vulnerable to post partum depression.