Estrogen‐related Mood Disorders: Reproductive Life Cycle Factors

  title={Estrogen‐related Mood Disorders: Reproductive Life Cycle Factors},
  author={S L Douma and Charles H. Husband and Mary Ellen O'Donnell and B. N. Barwin and A. Kirsten Woodend},
  journal={Advances in Nursing Science},
Women are at higher risk throughout their reproductive lives than are men for major depression. Numerous molecular and clinical studies have implicated estrogen in modulating brain function including that related to mood. In an attempt to present a conceptual model, the literature of the past 30 years on mood and well-being throughout reproductive life is reviewed as it relates to activity of endogenous, bio-identical, and synthetic estrogen in women. Results indicate that sudden estrogen… 

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  • J. Payne
  • Psychology
    International review of psychiatry
  • 2003
The evidence for the role of hormonal fluctuations, specifically estrogen, in triggering depressive symptoms in a subgroup of women is summarized and the potential role of estrogen in triggering depression symptoms via its effects on the serotonergic system, brain-derived neurotrophic factor and Protein Kinase C is reviewed.

Hormones and mood: from menarche to menopause and beyond.

Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women.

This small study suggests that for some antidepressant-naive perimenopausal women with clinical depression, ERT may have antidepressant efficacy in depressed women who have minimal response to a selective serotonin reuptake inhibitor.

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Current data support a relationship between oestrogen and psychological well-being and suggest improvement in such symptoms via hormonal therapies or other interventions will probably lead to better quality of life for women and may actually impede the deterioration associated with ageing and certain medical illnesses.

The impact of testosterone imbalance on depression and women's health.

Menopause-related affective disorders: a justification for further study.

The authors identify a number of methodologic problems in earlier studies and suggest that further study is warranted and that it is premature to conclude that menopause-related affective syndromes do not exist, but provide guidelines for examining mood and behavioral changes that take place during the climacteric andMenopause.

The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause. A hypothesis and review of supporting data.

  • J. C. Arpels
  • Psychology, Biology
    The Journal of reproductive medicine
  • 1996
A theory to help unify the symptoms of premenstrual syndrome, postpartum blues and depression, the perimenopausal transition and menopause is proposed that whenever brain estrogen levels fall below the minimum brain estrogen requirement, brain center dysfunction may ensue.

Estrogen Receptor Gene Expression in Relation to Neuropsychiatric Disorders

The discrete anatomical organization of the ER mRNAs in the human brain provide evidence as to the specific neuronal populations in which the actions of ERs could modulate mood and thus underlie the neuropathology of psychiatric disorders such as depression.

Effects of gonadal steroids in women with a history of postpartum depression.

The data provide direct evidence in support of the involvement of the reproductive hormones estrogen and progesterone in the development of postpartum depression in a subgroup of women and suggest that women with a history of post partum depression are differentially sensitive to mood-destabilizing effects of gonadal steroids.