Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function

@inproceedings{Gupte2015EstrogenAE,
  title={Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function},
  author={Anisha A. Gupte and Henry J. Pownall and Dale J. Hamilton},
  booktitle={Journal of diabetes research},
  year={2015}
}
Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-α elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate… CONTINUE READING