Estrogen: A master regulator of bioenergetic systems in the brain and body

@article{Rettberg2014EstrogenAM,
  title={Estrogen: A master regulator of bioenergetic systems in the brain and body},
  author={Jamaica R. Rettberg and Jia Ling Yao and Roberta Diaz Brinton},
  journal={Frontiers in Neuroendocrinology},
  year={2014},
  volume={35},
  pages={8-30}
}
Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects against adiposity, insulin resistance, and type II diabetes, and regulates energy intake and expenditure. During menopause, decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised… CONTINUE READING
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