Estrogen, astrocytes and the neuroendocrine control of metabolism

  title={Estrogen, astrocytes and the neuroendocrine control of metabolism},
  author={Esther Fuente-Martin and Cristina Garc{\'i}a-C{\'a}ceres and Eugenia Morselli and Deborah J. Clegg and Julie A Chowen and Brian Finan and Roberta Dı́az Brinton and Matthias H Tsch{\"o}p},
  booktitle={Reviews in Endocrine and Metabolic Disorders},
Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonadal hormones. Specifically, estrogens have been demonstrated to regulate metabolism perhaps by acting as a leptin mimetic in the central nervous system (CNS). CNS estrogen receptors (ERs) include ER… CONTINUE READING
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17beta-oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor beta-mediated neuroglobin up-regulation

  • E De Marinis, E Acaz-Fonseca, MA Arevalo, P Ascenzi, M Fiocchetti, M Marino
  • J Neuroendocrinol
  • 2013

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