Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis

@article{Palaszynski2004EstriolTA,
  title={Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis},
  author={Karen M Palaszynski and Hongbiao Liu and Kyi Kyi Loo and Rhonda R. Voskuhl},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={149},
  pages={84-89}
}
Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERalpha and ERbeta, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific… CONTINUE READING

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