Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial
@article{Voskuhl2016EstriolCW, title={Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial}, author={R. Voskuhl and H. Wang and T. Wu and N. Sicotte and R. Elashoff}, journal={The Lancet Neurology}, year={2016}, volume={15}, pages={35-46} }
BACKGROUND
Relapses of multiple sclerosis decrease during pregnancy, when the hormone estriol is increased. Estriol treatment is anti-inflammatory and neuroprotective in preclinical studies. In a small single-arm study of people with multiple sclerosis estriol reduced gadolinium-enhancing lesions and was favourably immunomodulatory. We assessed whether estriol treatment reduces multiple sclerosis relapses in women.
METHODS
We did a randomised, double-blind, placebo-controlled phase 2 trial at… CONTINUE READING
Supplemental Clinical Trials
Interventional Clinical Trial
This is a double-blinded, placebo controlled study of estriol pills versus placebo pills in
relapsing remitting multiple sclerosis. The study treatment will be an added on to Copaxone… Expand
Conditions | Relapsing Remitting Multiple Sclerosis |
---|---|
Intervention | Drug |
Topics from this paper
Paper Mentions
Interventional Clinical Trial
Approximately 50% of people diagnosed with Multiple Sclerosis (MS) will develop problems with
cognition. Currently, there are no FDA-approved treatments targeting cognitive function in… Expand
Conditions | Primary-progressive Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis |
---|---|
Intervention | Drug, Other |
Interventional Clinical Trial
Duavee is a hormone receptor modulator that has been approved for the treatment of menopausal
symptoms in menopausal women. The goal of this 8-week randomized, double blind, placebo… Expand
Conditions | Menopause, Multiple Sclerosis |
---|---|
Intervention | Drug |
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