Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial

@article{Voskuhl2016EstriolCW,
  title={Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial},
  author={R. Voskuhl and H. Wang and T. Wu and N. Sicotte and R. Elashoff},
  journal={The Lancet Neurology},
  year={2016},
  volume={15},
  pages={35-46}
}
  • R. Voskuhl, H. Wang, +2 authors R. Elashoff
  • Published 2016
  • Medicine
  • The Lancet Neurology
  • BACKGROUND Relapses of multiple sclerosis decrease during pregnancy, when the hormone estriol is increased. Estriol treatment is anti-inflammatory and neuroprotective in preclinical studies. In a small single-arm study of people with multiple sclerosis estriol reduced gadolinium-enhancing lesions and was favourably immunomodulatory. We assessed whether estriol treatment reduces multiple sclerosis relapses in women. METHODS We did a randomised, double-blind, placebo-controlled phase 2 trial at… CONTINUE READING
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