Estramustine binding protein in human brain-tumor tissue.

  title={Estramustine binding protein in human brain-tumor tissue.},
  author={Eva von Schoultz and Tommy A. Bergenheim and Kjell Grankvist and Roger Henriksson},
  journal={Journal of neurosurgery},
  volume={74 6},
Estramustine, an estradiol-17 beta and nornitrogen mustard complex, is used in the treatment of advanced prostatic carcinoma. A specific estramustine binding protein (EMBP) is important for its cytotoxic action, and the presence of EMBP has previously been demonstrated in rat and human prostatic cancer tissue. Significant levels of EMBP were detected by radioimmunoassay in human brain-tumor tissue. The EMBP concentrations (expressed as ng/mg protein) in 16 astrocytomas (mean 2.6 ng/mg, range 0… CONTINUE READING
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