Estradiol treatment of acromegaly. Reduction of immunoreactive somatomedin-C and improvement in metabolic status.

@article{Clemmons1980EstradiolTO,
  title={Estradiol treatment of acromegaly. Reduction of immunoreactive somatomedin-C and improvement in metabolic status.},
  author={David Robert Clemmons and Louis E. Underwood and Eli Chester Ridgway and B Kliman and R. N. Kjellberg and Judson J Van Wyk},
  journal={The American journal of medicine},
  year={1980},
  volume={69 4},
  pages={571-5}
}
Administration of estrogens to acromegalic patients has been shown to reduce the serum concentrations of bioassayable somatomedin and to cause improvement in clinical status. These effects appear not to result from an effect on the secretion of growth hormone since growth hormone concentrations are not consistently reduced. Using a sensitive radioimmunoassay for somatomedin-C, we have assessed the relationship between the estrogen-induced reduction of somatomedin-C and changes in several… CONTINUE READING