Estradiol therapy and breast cancer risk in perimenopausal and postmenopausal women: a systematic review and meta-analysis

@article{Yang2017EstradiolTA,
  title={Estradiol therapy and breast cancer risk in perimenopausal and postmenopausal women: a systematic review and meta-analysis},
  author={Zhilan Yang and Ying Hu and Jing Zhang and Liangzhi Xu and Rujun Zeng and Deying Kang},
  journal={Gynecological Endocrinology},
  year={2017},
  volume={33},
  pages={87 - 92}
}
Abstract Objective: To investigate the association between estradiol therapy and incidence of breast cancer, taking into consideration of different types of combined progestogen, the duration of exposure and the type of regimen. Method: A systematic review and meta-analysis. Result: A total of 14 studies were included in our study. In estradiol-only therapy analysis, meta-analysis resulted a pooled OR =0.90, 95% CI (0.40, 2.02) from the RCTs and pooled OR = 1.11, 95% CI (0.98, 1.27) from… 

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