Estradiol sustained release from high affinity cyclodextrin hydrogels.

@article{RodrguezTenreiro2007EstradiolSR,
  title={Estradiol sustained release from high affinity cyclodextrin hydrogels.},
  author={Carmen Rodr{\'i}guez-Tenreiro and Carmen Alvarez-Lorenzo and Ana Cecilia Rodr{\'i}guez-P{\'e}rez and Angel Concheiro and Juan J. Torres-Labandeira},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={66 1},
  pages={
          55-62
        }
}
Hydrogels for loading estradiol and controlling its release were prepared cross-linking various cyclodextrins with ethyleneglycol diglycidylether. To select the more adequate cyclodextrins, estradiol solubility diagrams in water with beta-cyclodextrin (betaCD), methyl-beta-cyclodextrin (MbetaCD), hydroxypropyl-beta-cyclodextrin (HPbetaCD), and sulfobutyl-beta-cyclodextrin (SBbetaCD) were made in absence and presence of hydroxypropyl methylcellulose (HPMC) applying or not autoclaving. Although… CONTINUE READING

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