Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women.

@article{Veldhuis2004EstradiolSM,
  title={Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women.},
  author={Johannes D. Veldhuis and Stacey M. Anderson and Petra Kok and Ali Iranmanesh and Jan Frystyk and Hans {\O}rskov and Daniel M. Keenan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 3},
  pages={
          1312-8
        }
}
The present study tests the mechanistic postulate that estrogen confers resistance to negative feedback by systemic IGF-I. To this end, eight postmenopausal women received a constant iv infusion of recombinant human (rh)IGF-I (10 micro g/kg.h x 6 h) and saline in randomized order on the 10th day of supplementation with oral estradiol (E(2)) and placebo (Pl). GH secretion was quantitated by 10-min blood sampling, immunochemiluminometry assay, and deconvolution analysis. Administration of E(2… CONTINUE READING

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