Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis.

@article{Mattingly2008EstradiolST,
  title={Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis.},
  author={Kathleen A. Mattingly and Margarita M. Ivanova and Krista A. Riggs and Nalinie S. Wickramasinghe and Margaret J. Barch and Carolyn M Klinge},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 3},
  pages={
          609-22
        }
}
Estrogen has direct and indirect effects on mitochondrial activity, but the mechanisms mediating these effects remain unclear. Others reported that long-term estradiol (E(2)) treatment increased nuclear respiratory factor-1 (NRF-1) protein in cerebral blood vessels of ovariectomized rats. NRF-1 is a transcription factor that regulates the expression of nuclear-encoded mitochondrial genes, e.g. mitochondrial transcription factor A (TFAM), that control transcription of the mitochondrial genome… CONTINUE READING