Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice.

@article{Moran2007EstradiolRR,
  title={Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice.},
  author={Amy L. Moran and Steven A Nelson and Rachel M Landisch and Gordon L Warren and Dawn A Lowe},
  journal={Journal of applied physiology},
  year={2007},
  volume={102 4},
  pages={
          1387-93
        }
}
Skeletal muscle contractility and myosin function decline following ovariectomy in mature female mice. In the present study we tested the hypothesis that estradiol replacement can reverse those declines. Four-month-old female C57BL/6 mice (n = 69) were ovariectomized (OVX) or sham operated. Some mice were treated immediately with placebo or 17beta-estradiol (OVX + E(2)) while other mice were treated 30 days postsurgery. Thirty or sixty days postsurgery, soleus muscles were assessed in vitro for… CONTINUE READING
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