Estradiol release from nanosuspensions based on solidified reverse micellar solutions ( SRMS )

Topical application of 17β-estradiol-hemihydrate (EST) as an oily solution shows positive effects in the treatment of postmenopausal keratoconjunctivitis sicca [1]. Due to low acceptance of oily systems for ophthalmic use, nanosuspensions based on solidified reverse micellar solutions (SRMS) are developed. SRMS, i.e. 1:1 (w/w) mixtures of lecithin and… (More)