Estradiol regulation of the human retinoic acid receptor alpha gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs.

@article{Rishi1995EstradiolRO,
  title={Estradiol regulation of the human retinoic acid receptor alpha gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs.},
  author={Arun K. Rishi and Z M Shao and Rosalie Baumann and Xuewei Serene Li and Mohmad Shafi Sheikh and Shioko Kimura and Nasser Bashirelahi and Joseph A. Fontana},
  journal={Cancer research},
  year={1995},
  volume={55 21},
  pages={4999-5006}
}
Estrogen receptor (ER)-positive human breast carcinoma (HBC) cell lines express significantly higher levels of retinoic acid receptor alpha (RAR alpha) (isoform 1) mRNA than ER-negative HBCs. Estradiol enhances RAR alpha mRNA expression in different ER-positive HBCs by 2-3-fold, which in turn results in increased sensitivity of ER-positive HBCs to the growth inhibitory effects of retinoic acid. To investigate the regulatory mechanisms of estradiol-mediated enhancement of RAR alpha mRNA… CONTINUE READING
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