Estradiol regulation of proopiomelanocortin gene expression and peptide content in the hypothalamus.

@article{Treiser1992EstradiolRO,
  title={Estradiol regulation of proopiomelanocortin gene expression and peptide content in the hypothalamus.},
  author={S L Treiser and Sharon L Wardlaw},
  journal={Neuroendocrinology},
  year={1992},
  volume={55 2},
  pages={167-73}
}
Previous studies have shown that the hypothalamic concentrations of beta-endorphin (beta-EP) and other proopiomelanocortin (POMC)-derived peptides change in the female rat following castration and gonadal steroid replacement. In this study we have measured POMC mRNA by solution hybridization assay in the medial basal hypothalamus (MBH) of ovariectomized rats treated with a regimen of estradiol (E2) that we have previously shown alters brain beta-EP peptide content. In addition the effect of… CONTINUE READING