Estradiol regulation of insulin-like growth factor-I expression in osteoblastic cells: evidence for transcriptional control.

@article{Ernst1991EstradiolRO,
  title={Estradiol regulation of insulin-like growth factor-I expression in osteoblastic cells: evidence for transcriptional control.},
  author={Matthias Ernst and Gideon A. Rodan},
  journal={Molecular endocrinology},
  year={1991},
  volume={5 8},
  pages={1081-9}
}
Insulin-like growth factor-I (IGF-I) has anabolic effects on skeletal tissues, acting as both a systemic hormone and an autocrine/paracrine regulator of cellular function. We have previously reported that estradiol (E2) stimulation of rat osteoblast proliferation in vitro was inhibited by IGF-I antibodies. We show here that E2, similar to IGF-I, also increases alpha 1(I) procollagen mRNA levels in primary cultures of rat calvarial osteoblasts. The E2 effect on collagen mRNA lags behind that… CONTINUE READING

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