Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats.

@article{Etgen1990EstradiolRT,
  title={Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats.},
  author={Anne M. Etgen and George B Karkanias},
  journal={Neurochemistry international},
  year={1990},
  volume={16 1},
  pages={1-9}
}
Present experiments examined whether previously observed hormone-dependent differences in norepinephrine-stimulated cAMP accumulation in hypothalamic and preoptic area slices are attributable to differences in noradrenergic receptor number or binding affinity. When compared to ovariectomized controls, hypothalamic and preoptic area membranes from estradiol-treated rats had significantly elevated numbers of [(3)H]prazosin (?(1)) binding sites. Estradiol affected neither the number of ?(1) sites… CONTINUE READING

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