Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

@article{Claassen2004EstradiolPC,
  title={Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage},
  author={Horst Claassen and Michael Schuenke and Bodo Kurz},
  journal={Cell and Tissue Research},
  year={2004},
  volume={319},
  pages={439-445}
}
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by incubating them with combined Fe2SO4, vitamin C, and hydrogen peroxide. The release of thiobarbituric-acid-reactive substances (TBARS, lipid peroxidation) and lactate dehydrogenase (LDH, membrane damage) was… CONTINUE READING
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