Estradiol protects against ischemic injury.

  title={Estradiol protects against ischemic injury.},
  author={Dena B. Dubal and Michael L. Kashon and Luther Creed Pettigrew and Jie Ren and Seth P. Finklestein and Shane W Rau and Phyllis M. Wise},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={18 11},
Clinical studies demonstrate that estrogen replacement therapy in postmenopausal women may enhance cognitive function and reduce neurodegeneration associated with Alzheimer's disease and stroke. This study assesses whether physiologic levels of estradiol prevent brain injury in an in vivo model of permanent focal ischemia. Sprague-Dawley rats were ovariectomized; they then were implanted, immediately or at the onset of ischemia, with capsules that produced physiologically low or physiologically… CONTINUE READING
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