Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

@article{Seillet2013EstradiolPF,
  title={Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.},
  author={Cyril Seillet and Nelly Rouqui{\'e} and Eliane Foulon and Victorine Douin-Echinard and Andr{\'e}e Krust and Pierre Chambon and Jill Arnal and J F Guery and Sophie Laffont},
  journal={Journal of immunology},
  year={2013},
  volume={190 11},
  pages={
          5459-70
        }
}
17β-Estradiol (E2) has been shown to regulate GM-CSF- or Flt3 ligand-driven dendritic cell (DC) development through estrogen receptor (ER) α signaling in myeloid progenitors. ERα regulates transcription of target genes through two distinct activation functions (AFs), AF-1 and AF-2, whose respective involvement varies in a cell type- or tissue-specific manner. In this study, we investigated the role of ERα AFs in the development and effector functions of inflammatory DCs, steady-state… CONTINUE READING
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