Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy.

@article{Sanchez2011EstradiolMO,
  title={Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy.},
  author={Maria Gabriela Baracat Sanchez and Erika Estrada-Camarena and Nancy B{\'e}langer and Marc P. Morissette and Th{\'e}r{\`e}se Di Paolo},
  journal={Neuropharmacology},
  year={2011},
  volume={60 4},
  pages={642-52}
}
Depression is common in Parkinson's disease and an imbalance in serotonin neurotransmission could be implicated. Estradiol is reported to modulate brain serotonin systems of rodents and monkeys, but this has not been explored in primate models of Parkinson's disease. Thus, the present study investigated the effect of estradiol on 5-HT(1A) and 5-HT(2A) serotonin receptors in the cortex, striatum and raphe nucleus of long-term ovariectomized hemiparkinsonian monkeys. Seven monkeys were… CONTINUE READING

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