Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

@article{Woolley1992EstradiolMF,
  title={Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.},
  author={Catherine S Woolley and Bruce S. McEwen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 7},
  pages={2549-54}
}
We have found that the density of synapses in the stratum radiatum of the hippocampal CA1 region in the adult female rat is sensitive to estradiol manipulation and fluctuates naturally as the levels of ovarian steroids vary during the 5 d estrous cycle. In both cases, low levels of estradiol are correlated with lower synapse density, while high estradiol levels are correlated with a higher density of synapses. These synaptic changes occur very rapidly in that within approximately 24 hr between… CONTINUE READING
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