Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5

@article{Peterson2014EstradiolMD,
  title={Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5},
  author={Brittni M. Peterson and Paul G Mermelstein and Robert L. Meisel},
  journal={Brain Structure and Function},
  year={2014},
  volume={220},
  pages={2415-2422}
}
Accumulating evidence from human and rodent studies suggests that females are more sensitive to the motivating and rewarding properties of drugs of abuse. Numerous reports implicate estradiol in enhancing drug-related responses in females, yet the neurobiological mechanisms underlying this effect of estradiol are unknown. Because dendritic spine plasticity in the nucleus accumbens (NAc) is linked to the addictive effects of drugs, we examined the influence of estradiol on dendritic spines in… CONTINUE READING
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