Estradiol-intranasal: a review of its use in the management of menopause.

  title={Estradiol-intranasal: a review of its use in the management of menopause.},
  author={Mukta Dooley and Caroline M. Spencer and Douglas Ormrod},
  volume={61 15},
UNLABELLED Estradiol-intranasal is a nasal spray formulation containing an aqueous solution of 17beta-estradiol that has a unique pulse-like pharmacokinetic profile. In a well designed, placebo-controlled trial estradiol-intranasal 200 to 400 microg/day significantly reduced the incidence and severity of climacteric symptoms in women with moderate to severe menopausal symptoms after 4 and 12 weeks' treatment. The efficacy of estradiol-intranasal 300 microg/day was similar to that of oral… CONTINUE READING


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