Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells.

Abstract

Rhodamine 123 is a fluorescent dye that localizes in mitochondria, is a substrate for the multidrug resistance pump, and is retained for long periods of time by carcinoma cells. 17 beta-Estradiol causes GH4C1 cells (rat pituitary tumor cells) to lose rhodamine 123 fluorescence faster than untreated cells. We found that estradiol induces accumulation of the… (More)

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@article{Jancis1993EstradiolIO, title={Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells.}, author={Erik M Jancis and Raquel Del Pilar Carbone and K J Loechner and Priscilla S. Dannies}, journal={Molecular pharmacology}, year={1993}, volume={43 1}, pages={51-6} }