Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat.

@article{Woolley1996EstradiolIT,
  title={Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat.},
  author={Catherine S Woolley and H. J{\"u}rgen Wenzel and Philip A. Schwartzkroin},
  journal={The Journal of comparative neurology},
  year={1996},
  volume={373 1},
  pages={108-17}
}
The effect of estradiol to increase the density of dendritic spines and axospinous synapses on hippocampal CA1 pyramidal cells in the adult female rat has been well-documented. However, presynaptic involvement in this process of synapse elimination and formation in the adult is unknown. To address this issue, we have reconstructed 410 complete presynaptic boutons through coded serial electron micrographs of CA1 stratum radiatum to determine the: (1) frequency of multiple (MSB) vs. single (SSB… CONTINUE READING