Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II.

@article{Oestreicher2006EstradiolIP,
  title={Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II.},
  author={Eveline M Oestreicher and Chang-jiang Guo and Ellen W. Seely and Tetsuro Kikuchi and Diego Martinez-Vasquez and L{\'a}rus J{\'o}nasson and Tai Yao and D. Burr and Sonia R Mayoral and Weranuj Roubsanthisuk and Vincent Ricchiuti and Gail K. Adler},
  journal={Kidney international},
  year={2006},
  volume={70 10},
  pages={1759-68}
}
Prospective, placebo-controlled clinical trials suggest that estrogen may have adverse effects on the vascular system in women. The goal of this study was to determine if 17beta-estradiol (E2) would have adverse effects on the renovasculature in a rat model of renal injury characterized by low nitric oxide (NO) and high angiotensin II (AngII). We studied female Wistar rats that were sham-operated (sham), ovariectomized (OVX), or ovariectomized and replaced with E2 (OVX/E2). All rats were… CONTINUE READING

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