Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.


Hematopoietic stem and progenitor cells reside in vascular and endosteal niches in the bone marrow. Factors affecting bone remodeling were reported to influence numbers and mobilization of hematopoietic stem cells. We therefore analyzed the effects of estradiol acting anabolic on bone integrity. Here we observe that estradiol increases progenitor cell… (More)
DOI: 10.3324/haematol.2011.052456