Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.

@article{Cid1994EstradiolEL,
  title={Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.},
  author={Mar{\'i}a del Carmen Cid and Hynda Karen Kleinman and Derrick S. Grant and H. William Schnaper and Anthony S Fauci and Gary S. Hoffman},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 1},
  pages={
          17-25
        }
}
Adhesion of leukocytes to endothelial cells is a critical step in the development of acute and chronic inflammatory lesions. We report here that estradiol treatment of cultured human umbilical vein endothelial cells stimulated up to a twofold increase in TNF-induced adhesion of both polymorphonuclear leukocytes and PMA-activated peripheral blood mononuclear cells. This effect was more evident (threefold increase) when endothelial cells were cultured on the basement membrane glycoprotein laminin… CONTINUE READING

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