Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum.

  title={Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum.},
  author={Ming Hu and Christopher J E Watson and Robert T Kennedy and Jill B Becker},
  volume={59 2},
Estradiol acts rapidly and directly to inhibit L-type Ca2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain gamma-aminobutyric acid (GABA), we hypothesized that estradiol inhibition of Ca2+ channel current in the cell body would result in decreased GABA release. In this study, we examined the effect of estradiol on the concentration of GABA, taurine, and glutamate in dialysate from striatum. In support of our hypothesis, the K+-evoked increase in GABA, but not… CONTINUE READING

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