Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells.

@article{Hnic2009EstradiolAE,
  title={Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells.},
  author={Emir H{\'e}nic and Vera Noskova and Gunilla H\oyer-Hansen and Stefan Hansson and Bertil Cassl{\'e}n},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2009},
  volume={19 2},
  pages={214-22}
}
Epidermal growth factor (EGF) stimulates proliferation and migration in ovarian cancer cells, and high tumor expression of the EGF system correlates with poor prognosis. Epidermal growth factor upregulates urokinase plasminogen activator receptor (uPAR) on the cell surface via 3 distinct mechanisms: rapid mobilization of uPAR from detergent-resistant domains, increased mRNA, and decreased degradation. G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER… CONTINUE READING
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