Estradiol as an antioxidant: incompatible with its physiological concentrations and function.

@article{Santanam1998EstradiolAA,
  title={Estradiol as an antioxidant: incompatible with its physiological concentrations and function.},
  author={Nalini Santanam and R A Shern-Brewer and R. McClatchey and Penny Z Castellano and Ana Alvarez Murphy and Steven V{\"o}lkel and Sampath Parthasarathy},
  journal={Journal of lipid research},
  year={1998},
  volume={39 11},
  pages={2111-8}
}
Estradiol has been documented to inhibit the oxidation of low density lipoprotein (LDL). We show that physiological concentrations of estradiol do not inhibit the oxidation of LDL by copper. LDL samples isolated from a) premenopausal and postmenopausal women and from b) women at different time periods during their menstrual cycle, who differ vastly in plasma estradiol levels, were also oxidized at the same rates by copper. In contrast, LDL samples isolated from c) women who were hyperstimulated… CONTINUE READING
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