Estradiol and its metabolites and their association with knee osteoarthritis.

  title={Estradiol and its metabolites and their association with knee osteoarthritis.},
  author={Maryfran R. Sowers and Daniel McConnell and Mary L. Jannausch and Ayse Buyuktur and Marc Hochberg and David A. Jamadar},
  journal={Arthritis and rheumatism},
  volume={54 8},
OBJECTIVE To determine if levels of endogenous estrogen or estrogen metabolites are associated with an increased risk of developing knee osteoarthritis (OA) in women. METHODS Serum estradiol (E2) and 2 urinary estrogen metabolites (2-hydroxyestrone and 16alpha-hydroxyestrone) with radiographically defined prevalent and incident knee OA in 842 white and African American women from the Southeast Michigan Arthritis Cohort. RESULTS The mean age and body mass index (BMI) of women in the cohort… CONTINUE READING
36 Citations
37 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Osteoarthritis and menopause

  • MF Sowers
  • San Diego (CA): Academic Press;
  • 2000

Similar Papers

Loading similar papers…