Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx.

@article{Zaitsu2007EstradiolAM,
  title={Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx.},
  author={Masafumi Zaitsu and Shin-ichiro Narita and K. Chad Lambert and James J. Grady and D. Mark Estes and Edward M. Curran and Edward Gautier Brooks and C. Scott Watson and Randall M. Goldblum and Terumi Midoro-Horiuti},
  journal={Molecular immunology},
  year={2007},
  volume={44 8},
  pages={1977-85}
}
BACKGROUND Allergic airway diseases are more common in females than in males during early adulthood. A relationship between female hormones and asthma prevalence and severity has been suggested, but the cellular and molecular mechanisms are not understood. OBJECTIVE To elucidate the mechanism(s) by which estrogens enhance the synthesis and release of mediators of acute hypersensitivity. METHODS Two mast cell/basophil cell lines (RBL-2H3 and HMC-1) and primary cultures of bone marrow derived… CONTINUE READING