Estradiol-activated alpha-fetoprotein suppresses the uterotropic response to estrogens.

  title={Estradiol-activated alpha-fetoprotein suppresses the uterotropic response to estrogens.},
  author={Gerald J. Mizejewski and M Vonnegut and Herbert I. Jacobson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={80 9},
The binding of estrogen to alpha-fetoprotein (AFP) in the plasma cannot account for the impaired estrogen response seen in immature rodents because estradiol (E2) doses that far exceed the total body burden of AFP will stimulate only modest uterine growth. We investigated this phenomenon in immature female mice by determining their uterine weights 23 hr after intraperitoneal injection of estrogens or AFP or both. Administration of either 0.5 micrograms of E2 or 10 ng of moxestrol (MOX… CONTINUE READING
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