Estradiol Stimulates Vasodilatory and Metabolic Pathways in Cultured Human Endothelial Cells

@inproceedings{Sobrino2009EstradiolSV,
  title={Estradiol Stimulates Vasodilatory and Metabolic Pathways in Cultured Human Endothelial Cells},
  author={Agua Sobrino and Manuel Mata and Andr{\'e}s Laguna-Fern{\'a}ndez and Susana Novella and Pilar J. Oviedo and Miguel A. Garc{\'i}a-P{\'e}rez and Juan Jos{\'e} Tar{\'i}n and Ampaeli Cano and Carlos Hermenegildo},
  booktitle={PloS one},
  year={2009}
}
Vascular effects of estradiol are being investigated because there are controversies among clinical and experimental studies. DNA microarrays were used to investigate global gene expression patterns in cultured human umbilical vein endothelial cells (HUVEC) exposed to 1 nmol/L estradiol for 24 hours. When compared to control, 187 genes were identified as differentially expressed with 1.9-fold change threshold. Supervised principal component analysis and hierarchical cluster analysis revealed… CONTINUE READING

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