Estradiol-17beta stimulates the renewal of spermatogonial stem cells in males.

@article{Miura1999Estradiol17betaST,
  title={Estradiol-17beta stimulates the renewal of spermatogonial stem cells in males.},
  author={Takeshi Miura and Chiemi Miura and Takayuki Ohta and Manal R. Nader and Takaaki Todo and Kohei Yamauchi},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={264 1},
  pages={
          230-4
        }
}
In this work, we examined the functions of the female hormone "estrogen" on spermatogenesis of the Japanese eel (Anguilla japonica). Estradiol-17beta (E(2)), a natural estrogen in vertebrates, was present in the serum and its receptor was expressed in the testis during the whole process of spermatogenesis. Spermatogonial stem cell renewal was promoted by E(2) implantation but was suppressed by tamoxifen (an antagonist of estrogen). In vitro, 10 pg/ml of E(2) was sufficient to induce… Expand
17beta-estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice.
TLDR
E2 has a dose-related mitogenic effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of sperMatogonia. Expand
In vitro effects of estradiol-17β on myoid and fibroblastic cell proliferation in the immature rainbow trout testis
TLDR
Results show that E2 can enhance interstitial cell proliferation in the immature rainbow trout testis before spermatogenesis begins. Expand
Estrogen response system in the reproductive tract of the male turtle: an immunocytochemical study.
Portions of the reproductive tract of the male (Trachemys scripta) turtle were examined by immunocytochemistry for evidence of the capacity to produce and respond to estrogen hormones (via theExpand
Japanese Eel: A Model for Analysis of Spermatogenesis
TLDR
In Japanese eel, the whole process of spermatogenesis is regulated by several sex steroid hormones, which causes an increase in the seminal plasma pH, enabling spermatozoa to motile and become capable of fertilization. Expand
The effect of estrogen on testicular gonocyte maturation.
TLDR
It is observed that the administration of E changed the migration of gonocytes towards the basal lamina, decreased cell proliferation and increased apoptosis, resulting in a decrease in spermatogonia and sarcoma, which could be one of the causes of infertility following exogenous E treatment. Expand
Analysis of Spermatogenesis Using an Eel Model
TLDR
Meiosis is induced by progestin; 17α,20β-dihydroxy-4-pregnen-3-one (DHP) through the action of trypsin, which regulates the sperm maturation through the regulation of seminal plasma pH. Expand
Spermatogenesis and its endocrine regulation
TLDR
Results from mammalian models suggest that during the later phases, the control of germ cell apoptosis via Sertoli cell factors is an important regulatory mechanism in spermatogenesis. Expand
Involvement of Sex Steroid Hormones in the Early Stages of Spermatogenesis in Japanese Huchen (Hucho perryi )1
TLDR
It is concluded that 11-KT is necessary for the initiation of spermatogenesis and sperm production, and it probably plays a role in spermiation, 17α,20β-DP is essential for the final maturation stage, could play a significant role in the mitosis phase and meiosis process, and probably participates in the regulation of spawning behavior. Expand
Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice
TLDR
Data which fuel this debate are summarized, with a particular attention to the recent results, obtained using type 1 cannabinoid receptor knockout male mice as animal model. Expand
Dual estrogenic regulation of the nuclear progestin receptor and spermatogonial renewal during gilthead seabream (Sparus aurata) spermatogenesis.
TLDR
A differential steroid regulation of Pgr expression during seabream spermatogenesis and the potential interplay of the E2/Era and 17,20βP/Pgr pathways for the maintenance of sperMatogonial renewal rather than entry into meiosis is suggested. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Human chorionic gonadotropin induces all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica).
TLDR
Evidence is obtained that human chorionic gonadotropin can induce the entire process of spermatogenesis, in vitro, from sperMatogonia to spermatozoa within 24 days and that this effect of gonadotropic substance is mediated through the actions of testicular somatic cells. Expand
Negative feedback control of the spermatogenic progression by testicular oestrogen synthesis: Insights from the shark testis model
  • M. Betka, G. Callard
  • Biology, Medicine
  • APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 1998
TLDR
The hypothesis that E synthesised within the testis is part of a negative feedback regulatory mechanism whereby more mature stages regulate the developmental advance of less mature stages is supported. Expand
Hormonal induction of all stages of spermatogenesis in germ‐somatic cell coculture from immature Japanese eel testis
TLDR
Results demonstrate that physical contact of germ cells to Sertoli cells is required for inducing spermatogenesis in response to 11‐KT, and establish a new culture system in which germ cells and somatic cells are cocultured after they are aggregated into pellets by centrifugation. Expand
cDNA cloning of a stage‐specific gene expressed during HCG‐induced spermatogenesis in the Japanese eel
TLDR
In situ hybridization analysis revealed that PCNA mRNA was expressed strongly in late type B spermatogonia before the sixth mitotic division, suggesting an involvement of PCNA in the progression of mitotic germ cells into meiosis during HCG‐induced sperMatogenesis in the eel. Expand
A role for oestrogens in the male reproductive system
TLDR
It is shown that oestrogen regulates the reabsorption of luminal fluid in the head of the epididymis, which raises further concern over the potential direct effects of environmental oestrogens on male reproduction and reported declines in human sperm counts. Expand
Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development.
TLDR
Data from DES and GnRHa treatments are interpreted as providing evidence for direct modulation of Sertoli cell (maturational) development by DES, and testis weight and daily sperm production were reduced in adulthood, but spermatogenesis was grossly normal. Expand
Two testicular cDNA clones suppressed by gonadotropin stimulation exhibit ZP2‐ and ZP3‐like structures in Japanese eel
TLDR
It is speculated that eSRS3 and eS RS4 may play important roles in the prevention of spermatogenesis in the eel, as both have amino acid sequences similar to those of the ZP‐domains of zona pellucida sperm‐binding protein (ZP‐2 and 3, respectively. Expand
The Effects of Testicular Tissue and Prehatching Inhibition of Estrogen Synthesis on the Development of Courtship and Copulatory Behavior in Zebra Finches
TLDR
The results suggest that while manipulations of steroid hormone exposure can influence the display of sexual behaviors, gonadal secretions may not be required for normal sexual differentiation of the song system in zebra finches. Expand
Molecular cloning and characterization of Japanese eel estrogen receptor cDNA
TLDR
A cDNA encoding the Japanese eel, Anguilla japonica, estrogen receptor (ER) was isolated and sequenced and a protein was produced that had high affinity for estradiol-17 beta (E2) and specifically bound estrogens. Expand
Masculine Sexual Behavior Is Disrupted in Male and Female Mice Lacking a Functional Estrogen Receptor α Gene
TLDR
It is clear that the ER alpha plays a key role in the expression of masculine sexual behavior and in the regulation of androgen receptors in a neuronal cell population involved in the display of motivated behaviors. Expand
...
1
2
...