Estradiol's effects on learning and neuronal morphology vary with route of administration.

@article{GarzaMeilandt2006EstradiolsEO,
  title={Estradiol's effects on learning and neuronal morphology vary with route of administration.},
  author={Annette Garza-Meilandt and Rebecca E Cantu and Brenda J. Claiborne},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 4},
  pages={
          905-16
        }
}
Estrogen's effects on performance and neuronal morphology are variable, and the reasons for this variability are not yet understood. In this study, the authors compared the effects of 2 delivery routes of 17 beta-estradiol on spatial learning and dendritic spine densities in young ovariectomized rats; estradiol was administered by implanted capsules or by daily oral gavage. Estradiol treatment via capsules improved performance in the radial-arm water maze and increased spine densities on… CONTINUE READING

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